* Toluene Levels in Blood and Brain of Rats;

data toluene_filee;



      date      yymmdd6.    rat              t_expose

      time_in   time8.   +1 time_out  time8.

   +1 time_nck  time8.   +1 time_bld  time8.

   +1 time_brn  time8.   +1 blood_no  $

      brain_no  $           weight

#2    bloodtl1 bloodtl2 braintol ppm_tolu age;



*convert micrograms per ml to micrograms per gram;

bloodtl1=bloodtl1/1.057;

bloodtl2=bloodtl2/1.057;

bloodtol=mean(bloodtl1,bloodtl2);



ln_bldtl=log(bloodtol);

ln_brntl=log(braintol);

ln_ppmtl=log(ppm_tolu);



format date yymmdd8.;

format t_expose ln_bldtl ln_brntl ln_ppmtl 8.3;

format braintol bloodtol 8.3;

format time_in time_out time_nck time_bld time_brn time8.;



LABEL DATE    ="Date Exposed"

      RAT     ="Rat # On A Given Day"

      T_EXPOSE="Nominal Minutes Of Toluene Exposure"

      TIME_IN ="Time Toluene Exposure Began"

      TIME_OUT="Time Toluene Exposure Terminated"

      TIME_NCK="Time Of Neck Break"

      TIME_BLD="Time Blood Drawn"

      TIME_BRN="Time Brain Sample Obtained"

      BLOOD_NO="Code For Blood Sample"

      BRAIN_NO="Code For Brain Sample"

      WEIGHT  ="Rat Body Weight In Grams"

      BLOODTL1="Sample1 Microgms/gm Toluene In Blood"

      BLOODTL2="Sample2 Microgms/gm Toluene In Blood"

      BLOODTOL="Microgms/gm Toluene in Blood"

      BRAINTOL="Microgms/gm Toluene in Brain"

      AGE     ="Age of Rat in Days at Time of Exposure"

      PPM_TOLU="Nominal ppm Toluene In the Chamber"

      LN_BLDTL="Log microgms/gm Toluene in Blood"

      LN_BRNTL="Log microgms/gm Toluene in Brain"

      LN_PPMTL="Log Nominal ppm Toluene in the Air";



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810211 1 180 07:10:00 10:10:00 10:10:15 10:11:23 10:12:02 F G 417

30.5 33.5 44.9 1000 93

810211 2 180 07:20:00 10:20:00 10:20:15 10:21:11 10:22:05 G B 351

36.1 33.5 35.5 1000 93

810211 3 180 07:30:00 10:30:00 10:30:16 10:31:05 10:31:50 H E 378

28.9 31.6 30.8 1000 93

810211 4 180 07:40:00 10:40:00 10:40:15 10:41:36 10:42:35 K A 338

29.5 31.3 38.5 1000 93

810211 5 180 07:50:00 10:50:00 10:50:32 10:51:33 10:52:21 A F 433

24.8 28.9 31.5 1000 93

810213 1 180 07:00:00 10:00:00 10:00:12 10:01:33 10:02:30 G F 393

.559 .609 .481 50 95

810213 2 180 07:10:00 10:10:00 10:10:11 10:11:12 10:12:03 C C 378

.519 .525 .584 50 95

810213 3 180 07:20:00 10:20:00 10:20:13 10:21:05 10:21:55 E E 450

.619 .669 .585 50 95

810213 4 180 07:30:00 10:30:00 10:30:17 10:31:11 10:32:07 J A 439

.793 .820 .628 50 95

810213 5 180 07:40:00 10:40:00 10:40:14 10:41:19 10:42:02 F B 397

.452 .435 .533 50 95

810217 1 180 07:15:00 10:15:00 10:15:16 10:16:04 10:16:44 Z G 301

.420 .420 .490 50 84

810217 2 180 07:25:00 10:25:00 10:25:11 10:26:32 10:27:25 B D 406

.554 .510 .719 50 84

810217 3 180 07:35:00 10:35:00 10:35:18 10:36:58 10:37:46 C B 302

.548 .580 .585 50 84

810217 4 180 07:45:00 10:45:00 10:45:16 10:46:29 10:47:17 D F 382

.561 .561 .675 50 84

810217 5 180 07:55:00 10:55:00 10:55:17 10:56:21 10:57:06 F A 355

.382 .430 .442 50 84

810218 1 180 07:10:00 10:10:00 10:10:14 10:11:40 10:12:25 D D 405

.220 .235 .492 50 85

810218 2 180 07:20:00 10:20:00 10:20:11 10:20:53 10:21:36 C B 405

.577 .589 .859 50 85

810218 3 180 07:30:00 10:30:00 10:30:13 10:32:09 10:32:55 A A 387

.448 .439 .650 50 85

810218 4 180 07:40:00 10:40:00 10:40:22 10:41:16 10:41:58 B E 358

.339 .346 .528 50 85

810218 5 180 07:50:00 10:50:00 10:50:11 10:51:32 10:52:08 E C 311

.412 .406 .546 50 85

810219 1 180 07:15:00 10:15:00 10:15:14 10:15:58 10:16:39 G F 355

1.063 1.127 1.262 100 86

810219 2 180 07:25:00 10:25:00 10:25:16 10:26:44 10:27:32 D C 440

1.130 1.121 1.584 100 86

810219 3 180 07:35:00 10:35:00 10:35:17 10:36:58 10:37:53 F B 421

1.146 . 1.773 100 86

810219 4 180 07:45:00 10:45:00 10:45:15 10:46:07 10:46:54 B D 370

.999 .996 1.307 100 86

810219 5 180 07:55:00 10:55:00 10:55:16 10:56:36 10:57:33 E E 375

1.051 1.051 1.338 100 86

810302 1 180 07:30:00 10:30:00 10:30:11 10:30:59 10:31:39 D D 368

1.211 1.211 1.180 100 83

810302 2 180 07:40:00 10:40:00 10:40:12 10:40:58 10:41:34 A F 321

1.417 1.050 1.108 100 83

810302 3 180 07:50:00 10:50:00 10:50:12 10:51:25 10:52:03 C A 359

.888 .872 .939 100 83

810302 4 180 08:00:00 11:00:00 11:00:17 11:01:40 11:02:33 B C 367

.658 .674 .909 100 83

810302 5 180 08:10:00 11:10:00 11:10:12 11:10:55 11:11:40 E B 363

.989 1.030 1.078 100 83

810304 1 180 07:10:00 10:10:00 10:10:09 10:11:20 10:12:03 B B 342

37.28 37.69 42.33 1000 85

810304 2 180 07:20:00 10:20:00 10:20:12 10:20:55 10:21:48 A C 319

36.34 32.80 34.03 1000 85

810304 3 180 07:30:00 10:30:00 10:30:09 10:30:52 10:31:32 C F 440

30.35 31.69 30.76 1000 85

810304 4 180 07:40:00 10:40:00 10:40:17 10:41:32 10:42:10 F D 363

27.46 28.52 32.36 1000 85

810304 5 180 07:50:00 10:50:00 10:50:13 10:50:52 10:51:30 D E 336

33.99 36.62 41.83 1000 85

810305 1 180 07:05:00 10:05:00 10:05:15 10:06:02 10:06:47 D F 378

41.58 42.01 54.93 1000 86

810305 2 180 07:15:00 10:15:00 10:15:16 10:16:05 10:16:56 B E 420

28.97 30.55 39.78 1000 86

810305 3 180 07:25:00 10:25:00 10:25:13 10:26:07 10:26:59 A C 346

28.97 25.21 49.29 1000 86

810305 4 180 07:35:00 10:35:00 10:35:13 10:35:51 10:36:34 G B 413

34.40 35.76 47.49 1000 86

810305 5 180 07:45:00 10:45:00 10:45:13 10:45:55 10:46:35 E A 432

34.62 36.21 42.66 1000 86

810316 1 180 07:10:00 10:10:00 10:10:21 10:11:39 10:12:24 D D 367

8.614 8.769 19.843 500 83

810316 2 180 07:20:00 10:20:00 10:20:18 10:21:03 10:21:45 C A 406

11.053 11.363 24.450 500 83

810316 3 180 07:30:00 10:30:00 10:30:12 10:30:58 10:31:35 E C 371

12.548 12.999 29.297 500 83

810316 4 180 07:40:00 10:40:00 10:40:15 10:41:16 10:42:07 A F 408

7.937 8.839 18.098 500 83

810316 5 180 07:50:00 10:50:00 10:50:12 10:50:50 10:51:40 F B 305

11.264 12.336 25.196 500 83

810317 1 180 07:10:00 10:10:00 10:10:12 10:11:02 10:11:46 F E 391

9.724 12.026 18.266 500 84

810317 2 180 07:20:00 10:20:00 10:20:22 10:21:24 10:22:07 C C 396

10.937 12.614 19.486 500 84

810317 3 180 07:30:00 10:30:00 10:30:12 10:31:20 10:32:04 B A 347

10.509 9.884 18.479 500 84

810317 4 180 07:40:00 10:40:00 10:40:10 10:40:48 10:41:29 E B 372

13.560 14.648 21.920 500 84

810317 5 180 07:50:00 10:50:00 10:50:19 10:51:00 10:51:39 D F 331

11.240 12.632 20.861 500 84

810318 1 180 07:10:00 10:10:00 10:10:35 10:11:15 10:12:02 C F 365

8.199 7.706 22.13 500 85

810318 2 180 07:20:00 10:20:00 10:20:11 10:21:16 10:22:02 G E 348

11.097 11.698 18.301 500 85

810318 3 180 07:30:00 10:30:00 10:30:12 10:30:58 10:31:41 A B 416

8.430 9.740 17.038 500 85

810318 4 180 07:40:00 10:40:00 10:40:17 10:41:02 10:41:42 B A 344

9.078 11.251 22.423 500 85

810318 5 180 07:50:00 10:50:00 10:50:18 10:51:33 10:52:06 D D 398

11.420 13.855 15.452 500 85

810319 1 180 07:10:00 10:10:00 10:10:21 10:12:09 10:13:16 B C 388

.745 .707 1.152 100 86

810319 2 180 07:20:00 10:20:00 10:20:14 10:21:09 10:21:50 A D 404

.803 .726 1.796 100 86

810319 3 180 07:30:00 10:30:00 10:30:12 10:31:02 10:32:09 G A 454

.784 .707 1.262 100 86

810319 4 180 07:40:00 10:40:00 10:40:14 10:40:57 10:41:45 C F 389

.707 .764 1.865 100 86

810319 5 180 07:50:00 10:50:00 10:50:15 10:50:56 10:51:33 H B 352

.898 .936 1.892 100 8610